The Benefits of Alpha Lipoic Acid – More than Just Skin Care

If we deliver Alpha Lipoic Acid to damaged skin will it help it?

If we deliver Alpha Lipoic Acid to damaged skin will it help it?


Every so often the airwaves fill with news about a new miracle substance that can cause skin tightening and make your skin young again, as if you magically had a neck lift or non-surgical face lift.  

Some of these substances are synthetic but most are compounds discovered from some sort of natural source, like a rare melon that is grown only in France or an even rarer orchid found only in a mysterious jungle somewhere.  Of course, the more rare the plant, the more expensive the product, which only increases the hype about it. 

Most of these substances are animated by the marketing hype about them, which points to the unfortunate fact that few, if any, of them actually undergo serious scientific research and clinical testing.  Most are like a flash in the pan, and as the media hype-wave passes, the substance recedes from memory in perfect timing with the arrival of the next new miracle substance promising miracle skin rejuvenation. 

On the other hand, a few of these substances actually do work, and some have been around long enough that scientific studies have validated some of the claims made in the media.  One such substance is Alpha Lipoic Acid. Alpha Lipoic Acid not only benefits your skin, but has many other important roles.

What is Alpha Lipoic Acid?

Alpha Lipoic Acid is found in every single cell in our bodies.

Alpha Lipoic Acid is found in every single cell in our bodies.

Alpha Lipoic acid is a naturally occurring substance found in many plants and animals and is also produced in our human bodies.  It has many important biochemical roles in human physiology and is found in every single cell in our bodies.

Some of the roles include:

1. It’s a Powerful Antioxidant

Alpha Lipoic acid is a powerful antioxidant that participates in many different physiological functions.

As we all know, oxidative damage also prematurely ages our skin, causing wrinkling, thinning and skin cancers.  Thus, anything that enhances our skin’s ability to fight oxidative damage, will also increase its heath, supporting skin tightening and skin rejuvenation.

Treatment of Cancer

Alpha Lipoic Acid is now commonly used as an “integrative oncology” IV therapy for various cancers with remarkable results, including pancreatic cancer.  The general medical establishment is quite negative about such out-of-the-box treatments, but associated clinical studies are solid, and no sane person can argue with the results.

For this article, our point is clear:  If ALA can help heal a patient with cancer, it certainly cannot hurt to use it for aging damaged skin, with wrinkles, jowls, acne, cystic acne or perhaps rosacea.

2. It’s a Generator of Cellular Activity 

It has a critical role as a “co-factor” in the generation of energy in every single cell.

More and more, in skincare clinics such as ours who practice advanced Integrative Medicine, IV therapy is becoming an integral and critical component of effective protocols for overall health and wellbeing, including that of the skin.

How Your Cells Generate Energy

Mitochondria are small “organelles” that exist inside each of our cells.

Mitochondria are small “organelles” that exist inside each of our cells.

Every cell in the body must generate its own energy.  Our bodies are NOT engineered like our neighborhoods, where a central power station feeds (supplies) each of our homes.  Every home must have its own energy generator.

Mitochondria are the Powerhouse of Every Cell

Every cell uses the same physiological “machine” to generate energy called Mitochondria.   Mitochondria are small “organelles” that exist inside each of our cells.  Within each mitochondria, the primary biochemical pathway that converts food into energy that the cell can use is called the Citric Acid Cycle.  Thus, carbohydrates and fats are converted into the molecule “ATP” which is the primary chemical “fuel” that cells use to live and function.  Alpha Lipoic Acid is a key component in this pathway.  Without Alpha Lipoic Acid the cycle would stop, our cells would not be able to produce energy to function (ATP), the cell would die and shortly thereafter so would we.

This applies to all the different types of cells that comprise the skin as well. If each of them is not fully functioning at the level of their mitochondria, the skin will deteriorate, prematurely age, wrinkle, sag, and become more susceptible to cancer.  On the other hand, treatments that energize the mitochondria of skin cells, will cause skin tightening, lifting, toning, and overall skin rejuvenation.  Such treatments should be combined with laser skin tightening, non-surgical facelift, skin resurfacing, neck lift, and any other protocol that is integrative in nature.

Ozone Knowledge Nugget

Ozone is known to energize mitochondria in a direct and profound way.  Though the scientific explanation goes beyond the scope of this article, I will address ozone in a forthcoming article.  For now know, that mitochondrial stimulation is the reason that our protocols combine ozone with CIA. (Collagen Induction Acupuncture).

3. It’s an Anti-Inflammatory

Alpha Lipoic Acid has mild anti-inflammatory properties.

Ever seen severely sun damaged skin?  Is there any doubt in your mind that it is chronically inflamed?  Thus, it is easy to see why Alpha Lipoic Acid benefits sun-damaged skin and is expected to have a profoundly curative anti-inflammatory effect on the skin.

4. It has Positive Anti-Aging Effects 

Alpha Lipoic Acid may have a positive “anti-aging” effect by inhibiting “cross bridging”.

The Science of Aging Skin

One of the biochemical characteristics of the aging process and aging tissue is the bonding together of molecules that should be separate.  These chemical bonds are referred to as cross-bridges. Though we do not understand why this occurs, proteins in tissues of older individuals tend to “cross-bridge”, which impairs their ability to function properly.  “Hardening of the arteries” (Arterial sclerosis) is an example of damage caused by cross-bridging, and so is wrinkling of skin.

5. It’s a Heavy Metal Detox

Lastly, Alpha Lipoic Acid can help our bodies remove toxic heavy metals.

ALA can help our bodies remove toxic heavy metals.

Some Metals are Good

Our bodies naturally use specific metals as a healthy and necessary part of our physiology.  Copper, iron, zinc, manganese, chromium, molybdenum and selenium are found in small quantities (referred to as “trace” elements) as important components of certain molecules.  A well-known example is the critical presence of iron in our hemoglobin. 

However, other metals, usually classified as “heavy metals” such as lead, mercury, cadmium and aluminum are toxic to us and do not play a role in our physiologies. When somehow we absorb them, they are not only toxic but hard to get rid of as well.  For example mercury that you inadvertently absorbed as a child, will remain in your body for life, causing toxic damage the entire time.

Chelation – Getting Rid of Toxic Heavy Metals

The process of getting rid of toxic heavy metals is called “chelation”. 

Biochemically speaking, the foreign heavy metal is bound to another molecule that the body can process through a filtering mechanism.  The body does this naturally but only to a limited extent.  Essentially, the foreign toxic heavy metal that the body doesn’t handle well, is “hitched” or “chelated” to a naturally occurring healthy molecule that the body is designed to handle… and the good molecule tows the toxic metal molecule through a filtering process that eliminates it through the urine or feces. 

When a person is carrying a significant heavy metal load, their body will need help in getting rid of it. In such cases, Chelation Therapy, wherein the patient takes therapeutic amounts of these healthy chelating compounds, either orally and/or through IV therapy, in order to detoxify from the toxic heavy metals.

How Alpha Lipoic Acid Works

The matter of solubility is a key factor. For instance, sugar and salt dissolve easily in water, but neither of them will dissolve in oil.

The matter of solubility is a key factor. For instance, sugar and salt dissolve easily in water, but neither of them will dissolve in oil.

One of the reasons that Alpha Lipoic Acid benefits our physiology and has so many roles is its unusual property of being soluble in both fat and water.  This unusual characteristic is called: “amphiphilic”.

It’s a Matter of Solubility

When it comes to the biochemistry of animal physiology, the matter of solubility is a key factor.  As we know from our experience in the kitchen, some substances can be dissolved in water and others only in oil. For instance, sugar and salt dissolve easily in water, but neither of them will dissolve in oil.  On the other hand butter will not dissolve in water, but does dissolve in fat or oil.

ALA is amphiphilic unlike oil and water.

ALA is amphiphilic unlike oil and water.

In fact everybody knows that “oil and water don’t mix”, which means that they do not dissolve in each other.  Therefore it stands to reason that a substance that dissolves in one of them will not dissolve in the other.  An exception to this would be an amphiphilic compound such as Alpha Lipoic Acid which dissolves in both.

Why is Solubility Important?

The reason properties of solubility are important is because animal physiology can be divided into two primary internal environments;

  1. Hydrous environments that are dominated by water, such as inside and outside of our cells (intracellular and extracellular environments)
  2. Anhydrous environments that are dominated by fats (lipids or oils), such as the membranes of our cells which are made up primarily of fats, lipid tissues such as the fat under our skin (subcutaneous fat), and certain organs such as breast tissue.

Thus, physiologically active chemicals such as vitamins that need to function in a water (hydrous) environment need to be water soluble, whereas vitamins that need to function in a fat (lipid) environment need to be fat soluble.

Knowledge Nugget

By the way, solubility is also a critically important consideration of the design of medications and their proper prescription.  For example, to be effective as a drug that fights a bladder infection it must be water soluble in order to collect and be active in the urine, whereas a drug that is engineered for breast tissue will need to be lipid soluble, as breast tissue is predominantly composed of lipids.

The Benefits of Alpha Lipoic Acid

Now that we know a few of the benefits of Alpha Lipoic Acid, is it good for our skin?

Now that we know a few of the benefits of Alpha Lipoic Acid, is it good for our skin?

There are a number of conditions for which ALA supplements have proven beneficial.

Does Alpha Lipoic Acid Benefit Your Skin?

Can ALA be good for our skin as a topical product?

Can ALA be good for our skin as a topical product?

Now that we know a few of the benefits of Alpha Lipoic Acid, the reason for this article is to address whether or not it can be good for our skin as either a topical or oral product.

Obviously all the different types of cells that we have in our skin benefit from what Alpha Lipoic Acid does for all cells.  (Functions 1-5 listed above)  So the critical question becomes, if we deliver Alpha Lipoic Acid to damaged skin will it help it?  Theoretically, it should help… but does it?

Science Doesn’t Really Know

Unfortunately, this is precisely where much medical science falls short.  Many things we think we understand about our physiology that lead us to developing a particular therapy or product that according to our ‘theories’ should work, don’t work when clinically tested. 

Often times even substances that work when tested on cell cultures in a laboratory setting, do not work when tested on living beings.  Worse yet, sometimes our theoretical therapies actually cause damage.

Knowledge Nugget

The truth is, that as much as we think we understand about our physiology, we are barely scratching the surface of its actual complexity. 

Indeed, every individual element of human physiology is complicated, and when millions of these elements are combined into a single interrelated, exquisitely balanced, complete and synergistic system… and then integrated into all the other dimensions of life that are beyond physiology… we end up with beings that are infinitely complex.

I am not the first to say such a thing… but exploring the “inner engineering” of human physiology is like touching the mind of God.

The Final Analysis of Alpha Lipoic Acid

In the case of Alpha Lipoic Acid and its benefits, some clinical testing has been conducted with encouraging, but not conclusive results. 

Topical products containing Alpha Lipoic Acid have reduced fine lines and wrinkles to various extents.  However, much more clinical testing is needed before a definitive conclusion about the efficacy of Alpha Lipoic Acid can be reached.  This can also be said about treating acne, cystic acne, rosacea, sun damaged skin, age spots and sun spots.

The good news is, that evidence does exist that Alpha Lipoic Acid benefits the skin and can help, and we know that it can’t hurt you.  This alone is progress when compared to other popular products that can cause irritation and even damage when overused such as Tretinoin (Retin-A, Renova), especially for people who are hypersensitive to it.

One last point.  Should you choose to use Alpha Lipoic Acid products, make sure that the product uses the ‘R’ form of Alpha Lipoic Acid, which is more effective than the ‘S’ form.

About the Authors


  1. Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997;29(3):315‐331. doi:10.1016/s0306-3623(96)00474-0
  2. Beitner H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. Br J Dermatol. 2003;149(4):841‐849. doi:10.1046/j.1365-2133.2003.05597.x
  3. Puizina-Ivić N, Mirić L, Carija A, Karlica D, Marasović D. Modern approach to topical treatment of aging skin. Coll Antropol. 2010;34(3):1145‐1153.
  4. Sherif S, Bendas ER, Badawy S. The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle. Eur J Pharm Biopharm. 2014;86(2):251‐259. doi:10.1016/j.ejpb.2013.09.008
  5. Salinthone S, Yadav V, Schillace RV, Bourdette DN, Carr DW. Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling. PLoS One. 2010;5(9):e13058. Published 2010 Sep 28. doi:10.1371/journal.pone.0013058
  6. Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care. 2006;29(11):2365‐2370. doi:10.2337/dc06-1216
  7. Golbidi S, Badran M, Laher I. Diabetes and alpha lipoic Acid. Front Pharmacol. 2011;2:69. Published 2011 Nov 17. doi:10.3389/fphar.2011.00069
  8. Salehi B, Berkay Yılmaz Y, Antika G, et al. Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. Biomolecules. 2019;9(8):356. Published 2019 Aug 9. doi:10.3390/biom9080356
  9. Ghibu S, Richard C, Delemasure S, Vergely C, Mogosan C, Muresan A. Un dithiol endogène aux propriétés antioxydantes: l’acide alpha-lipoïque, utilisation potentielle dans les pathologies cardiovasculaires [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases]. Ann Cardiol Angeiol (Paris). 2008;57(3):161‐165. doi:10.1016/j.ancard.2008.02.018
  10. Silvestri S, Orlando P, Armeni T, et al. Coenzyme Q10 and α-lipoic acid: antioxidant and pro-oxidant effects in plasma and peripheral blood lymphocytes of supplemented subjects. J Clin Biochem Nutr. 2015;57(1):21‐26. doi:10.3164/jcbn.14-130
  11. Skibska B, Goraca A. The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress. Oxid Med Cell Longev. 2015;2015:313021. doi:10.1155/2015/313021
  12. Suh JH, Moreau R, Heath SH, Hagen TM. Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. Redox Rep. 2005;10(1):52‐60. doi:10.1179/135100005X21624
  13. Berkson, Burton & Rubin, Daniel & Berkson, Arthur. (2009). Revisiting the ALA/N ( -Lipoic Acid/Low-Dose Naltrexone) Protocol for People With Metastatic and Nonmetastatic Pancreatic Cancer: A Report of 3 New Cases. Integrative cancer therapies. 8. 416-22. 10.1177/1534735409352082.
  14. Di Geronimo G, Caccese AF, Caruso L, Soldati A, Passaretti U. Treatment of carpal tunnel syndrome with alpha-lipoic acidEur Rev Med Pharmacol Sci. 2009;13(2):133‐139.
  15. Scaramuzza A, Giani E, Redaelli F, et al. Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot TrialJ Diabetes Res. 2015;2015:474561. doi:10.1155/2015/474561
  16. Skibska B, Goraca A. The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stressOxid Med Cell Longev. 2015;2015:313021. doi:10.1155/2015/313021

Page originally published on January 6, 2018. Last reviewed on February 10, 2021 by Alice Pien, MD and Asher Milgrom, PhD.