Mesenchymal Stem Cell Therapy
What, why, where, when should I consider treatment with mesenchymal stem cells (biological allograft)?
Watch the 4 part video series : The real science of stem cells
Stems Cells are the Regenerative Engines of Our Bodies
Simply put, every cell in every organ and tissue of our bodies have a programed life cycle:
- Stem Cells create every cell.
- The cells work at full capacity for as long as they can.
- Eventually all cells lose their ability to function because of age or becoming damaged in some way.
- Every cell then dies a “programed death”.
- Finally, the cycle starts again as stem cells replace the dying cells with new cells.
The fact is, your entire body originated from a collection of exceptionally powerful stem cells that burst into life when the egg and sperm from which you came fused to become a tiny fetus. Then, as the fetus that turned into you developed different specialized organ systems and tissues, stem cells also specialized to become a functional part of each of these organ systems and tissues. Thus, for example, when a liver cell dies and needs to be replaced, local stem cells in the liver create the new liver cell…. And so it is with all our organs.
As We Age Our Stem Cells Lose Their Regenerative Capacity
Unfortunately, as we age we slowly lose our regenerative capacity, because:
- We lose vast numbers of our stem cells, and
- The stem cells that remain are far less energetic and capable as the stem cells we had when we were younger.
Stem Cell Therapy and the Science of Regenerative Medicine
That is why an entire new science of Regenerative Medicine is attracting so much attention. After all, if we could fill all our organs with happy, healthy and energetic stem cells (biological allograft), imagine how long and strong we could live!!
Therefore, Regenerative Medicine focuses on two separate and complimentary goals:
- Stimulate your own native stem cells… with the goal of increasing their numbers and energizing their ability to function.
- Inject into your body stem cells (biological allograft) from other sources that can do for you what your own stem cells are no longer able to do.
There are two distinct types of stem cells that can be used this way:
- Your own stem cells, (autologous) usually harvested from your bone marrow or fat.
- Embryonic stem cells, (allogenic) harvested from embryonic tissues such as umbilical cords. These young stem cells (biological allograft) are typically much more potent that autologous stem cells.
The Different Types of Stem Cell Therapies
Therapies that utilize injected or infused stem cells (biological allograft) include:
Joint repair – Stem Cells (biological allograft) injected into joint
Autoimmune disease – Stem Cells (biological allograft) infused by IV into blood and/or IM injection into muscle
Degenerative Organs – Stem Cells (biological allograft) infused by IV into blood and/or IM injection into muscle
Neuro & Neuro Muscular Disease – Stem Cells (biological allograft) infused by IV into blood and/or IM injection into muscle
Stem Cell Therapy is also used as the most promising and potent of all anti-aging, longevity and vitality therapies.
Why We Use Umbilical Cord “Wharton’s Jelly” Mesenchymal Stem Cells
Every day we are asked about stem cells, where they come from, how they work, and about the comparison between using “Adult Stem Cells” vs using “Embryonic / Placental Stem-Cells” (biological allograft) such as those derived from umbilical cords, amniotic fluid, or cord blood. (FYI, fetal stem cells taken from fetuses are never used) Hopefully, you have watched our 4-part video that answers most of these questions… The Real Science of Stem Cells
Therefore, to satisfy everyone’s curiosity, every now and then I like to share with you and the millions of our viewers, some of the newest and most advanced research that confirms what we have been teaching and further reinforces your understanding of why treatments using Wharton’s Jelly Umbilical Cord Stem Cells (biological allograft) provide the best possible clinical results for you. Bottom line, whether you receive stem cell treatments from us or another reputable clinic, we want you to be as informed as possible and have as much confidence as possible that you are doing the “right thing” for your body and your life.
Umbilical Cord Wharton’s Jelly Stem Cells (WJ MSC) were only recently discovered 10 years ago. During these last 10 years the research on WJ MSCs has experienced an explosion of data generated from universities and laboratories throughout the world. The quotes I have included below are excerpts from one of many recent and reputable scientific articles posted in the USA National Institute of Health (NIH) website for important scientific advancements in the fields of Medicine and health sciences. See: “Mesenchymal Stromal Cells From Wharton’s Jelly (WJ MSCs): Coupling Their Hidden Differentiative Program to Their Frank Immunomodulatory Phenotype“
1. The Most Useful of all Stem Cells
“Mesenchymal Stem Cells isolated from human umbilical cord Wharton’s jelly constitute a particularly interesting population in that they have shown an exceptional and unsurpassed plasticity in vitro and in vivo.”
What is the significance of this statement? Our WJ MSCs are clinically useful in treating many different kinds of conditions throughout many organ systems in the human body. In fact, they are the MOST useful of all stem cell types. As the article states, WJ MSCs have “greatly expanded the clinical indications for these cells in regenerative medicine”.
2. Autoimmune Disease
This means that in addition to: the re-population-type cell therapy approach, (where the new stem cells rebuild the tissue of damaged organs) as in a support-type regenerative medicine approach, these cells may provide anti-inflammatory and immune-modulation activities that may promote the organ self-repair, even in diseases in which the physiological reparative processes are hampered by the underlying disease.
That explains why WJ MSCs seem to be so effective in treating autoimmune diseases, such as Rheumatoid Arthritis (RA), Lupus, Hashimoto’s Thyroid Disease, Multiple Sclerosis (MS), Psoriasis, Fibromyalgia and so many other autoimmune diseases.
3. Orthopedic Injury and Disease
This means that WJ Mesenchymal Stem Cells are effective when used to repair damaged joints, cartilage, bones, ligaments… basically all sorts of damage usually handled by orthopedic surgeons. Whether you are a professional athlete who needs to keep your joints strong or just love to play your favorite sport and your joints are stiff and hurting… or even in the case where you need orthopedic surgery but want to avoid it, Regenerative Medicine treatments with WJ Mesenchymal Stem Cells might prove to be your very best option.
4. Completely Safe from Immune Rejection
WJ Mesenchymal Stem Cells are completely safe to use with respect to our immune systems, in that they never cause an immune (rejection) reaction by the patient receiving the cells.
5. Organ Disease and Replacement
A number of diseases, which in their final stages require organ transplant or cellular therapy, derive from or are accompanied by an unbalance in the organ inflammatory or immune state. To this regard, the use of a cellular therapy vehicle, which may provide both organ recellularization and restoration of a physiological microenvironment, may be a further benefit for patients.
There are many people who are suffering from various conditions that cause massive inflammation throughout there physiology. Unfortunately, such systemic inflammation over prolonged periods of time often cause organ damage. Our WJ MSCs have the power to stop an inflammatory disease that is destroying an organ such as a liver or kidney.
6. Liver Disease Therapy
Our WJ MSCs are good for stopping the progression of liver disease, and rebuilding new and healthy liver tissue. Therefore, if (God forbid) you are suffering from a progressively deteriorating organ disease, that is heading toward the need for an organ transplant, it is possible that our WJ Mesenchymal Stem Cells might be able to stop the progression of the disease and even reverse it, thereby bringing your diseased organs back to health.
7. Diabetes, a Possible Cure
Research shows that these cells can be successfully differentiated into IPCs (insulin producing cells)… this promising data suggest that WJ MSCs possess the ability, both in vitro and in vivo, to differentiate into insulin-secreting cells.
We are seeing in numerous clinical studies, that diseases previously considered lifelong afflictions that at best could be managed but never cured, might actually be able to be arrested and even cured.
WJ MSCs may be administered to type I diabetes patients, and the treatment is safe and prospectively effective. Clinical parameters such as Hemoglobin A1c and C peptide were significantly better … suggesting that the implantation of WJ MSCs for the treatment of newly onset Type 1 Diabetes may be safe and effective.
8. Neurological Disease – Heart Disease
WJ MSCs have been successfully differentiated toward cells of other mature organs such as neural cells, skin follicular cells, cardiomyocytes. This means that our WJ Mesenchymal Stem Cells might be the key to treating neurological diseases or damaged nerves or heart diseases!
Patient Stories – Their Experience with Stem Cell Therapy
Dr. John Gray – My Experience with Stem Cell Knee Injections
“Hi I’m Dr. John Gray author of Men Are from Mars, Women Are from Venus. I came to AMA Regenerative Medicine because I couldn’t walk on my right leg. I did the umbilical cord stem cell treatment and it blew my mind…
… If somebody is considering stem cell treatments they are really lucky. This is life transformational, basic and easy. Your body does it for you. It’s fantastic!”
Sharan – My Amazing Lupus Treatment with Mesenchymal Stem Cells
“Hello, My name is Sharan, I’m 18 years old and I was diagnosed with Lupus when I was 14…
… If you are suffering from Lupus there is a solution. Never listen to the doctors when they tell you there is no cure or there’s no solution. The mesenchymal stem cell treatments heal your body to the root of the cause. It provides you with a lot of relief.”
Michael – My Experience with Stem Cell Injections for Back Pain
“My name is Michael. I’m a Veteran of almost 17 years in the Navy and the Army. I hurt my back on active duty and I’ve been in chronic pain for almost ten years. Ten years…
… After the first round of stem cell injections I felt so much better. I can’t imagine life without this treatment. My days before when I was injured I can’t even describe it now. It’s like somebody else’s life.”
Former N.Y. Yankee Jim Leyritz – My Experience with Ozone and Stem Cell Injections
“I’m Jim Leyritz, former 2 time World Series Champion with the Yankees. I was a catcher in the major leagues for almost 20 years. I have been receiving Ozone and Stem Cell injections to help with my injuries and pain…
… I’m able to run again but more importantly I don’t have to take 6 to 10 Advil every day for the pain, for the swelling and things like that. My body is just naturally doing it because of the ozone injections and because of the treatments I am receiving with the ozone therapy.”
My Stem Cell Knee Injections for ACL and Meniscus Damage
“My name is Reynolds. I hyper-extended my left knee which had previously suffered an ACL tear and also meniscus damage and from that point forward I knew something was wrong with my knee again…
… I can tell you that in literally days of having the stem cells put in there I could feel as if my knee was beginning to repair itself. That has progressed on a regular basis since that time. I would say at this point in time after 5 weeks and certainly not completely through the benefits of the stem cell as well as the ozone therapy that it’s at least 95% of where it ought to be.”
Susan – How I Avoided Knee Replacement Surgery with Stem Cell Injections
“Hi I’m Susan and I have had a life long battle with bad knees due to a hereditary lack of cartilage…
… The results of the stem cell injections have been short of life giving as far as my knees are concerned. I don’t even see surgery on my horizon right now.”
Gavin – How I Quickly Recovered from Open Heart Surgery
“My name is Gavin. I had a quadruple bypass. I’ve been a vegetarian my whole life…
… It feels like a construction site in me after I have the stem cells. The stem cells just go to town in me when you put them in. 2 weeks after my quadruple bypass I got signed off by my surgeon.”
Jeff – How I Got Relief From Rotator Cuff Shoulder Pain with Stem Cells
“Hi I’m Jeff. What created the need for me to get relief from the pain in the rotator cuff of my shoulder was that I’m very athletic…
… The stem cell therapy treatments she has done have been unbelievable in giving me the pain relief I needed in my shoulders. It’s something you notice within a day or two of getting the shoulder pain treatments and within a week or two the pain is completely gone.”
Stem Cell Therapy FAQs
Q. Is Stem Cell Therapy with mesenchymal stem cells safe?
A. Yes. Treatment with mesenchymal stem cells (biological allograft) is completely safe.
Many major universities around the world are deeply engaged in stem cell research and the use of these cells in various therapies. Not a single negative complication when using these cells has been reported.
Treatments with stem cells (biological allograft) are viewed by many leaders in the field of regenerative medicine as the best hope humanity has of reversing many diseases that have long been considered terminal.
Q. Do the stem cells you use come from the Riordan Clinic in Panama?
A. No. However, like the Stem Cell Institute Panama, our source of stem cells (biological allograft) is also harvested from the umbilical cord Wharton’s Jelly and known as mesenchymal stem cells (MSC). Dr. Arnold Caplan of Case Western discovered and defined these cells.
One of the few FDA approved labs that specializes in harvesting these stem cells (biological allograft) is were we acquire them. These cells are primarily used for stem cell research studies conducted by major universities around the world.
We highly recommend that you take advantage of Dr. Riordan’s lectures. Dr. Riordan – is the world reigning expert in Stem Cell R&D.
Q. How many stem cell injections are needed before I feel a difference in my joint?
A. The pain relief is usually fantastic following the first injection. In fact, we need to continuously remind our patients not to “over do it” immediately following treatment. The pain will significantly diminish but healing and regeneration have not yet occurred. Refrain from heavy activity until the joint has had time to fully heal.
In regards to how many stem cell (biological allograft) injections will be needed, it depends on the source of the damage to your joint, the severity of the damage and how old the damage is. 2 to 3 injections could be needed.
Q. How often are the stem cell injections needed?
A. Great question! Stem Cell Therapy is not “done and over”, when it’s “done in over”, like surgery is.
Regenerative Medicine works with a patient’s physiology. The patient’s physiology is stimulated to do the the things it used to do when the patient was much younger and in excellent health. For instance, when a person is younger, their joints are stronger and can withstand much more exertion. In the case of a damaged joint, they can often heal themselves of minor injuries as well. The regenerative capacity of a younger physiology is much greater than an older one. Therefore, tapping into that regenerative capacity, to stimulate it and amplify it, is the goal of Regenerative Medicine. In this way the body will heal itself. Stem cell therapy does exactly that.
Exactly how many stem cell (biological allograft) injections will be needed and at what frequency really depends on the patient. What caused the damage, how damaged the joint is and how long the joint has been damaged. Many patients only need 1 stem cell (biological allograft) injection. Some patient’s need 2 to 3 injections. To achieve a good clinical result we have never had to inject a joint more than 3 times.
Q. How long from the time of the stem cell injection does it take to experience relief and increased functionality?
A. The changes start immediately… and go through a sequence of healing and regenerative phases that max out around 6 months.
If more stem cells (biological allograft) are needed, typically they will be administered between months 4-6.
Q. I have shoulder pain. How quickly will I get relief?
A. Prior to infusing the stem cells (biological allograft), an anesthetic is injected into the joint, so the relief from pain in the joint is dramatic and immediate. However, this pain relief is temporary as it takes about an hour before the anesthetic wears off.
Even after the anesthetic has worn off, significant reduction in pain is experienced by most patients. This is because the special formulation that includes the stem cells (biological allograft) is such an effective anti-inflammatory. From patient to patient the sensations in the damaged joint will vary. Below is what most patients report when they undergo the Stem Cell Therapy treatments:
- The treatment is not painful and many don’t feel it at all.
- Following the treatment, the joint is much more comfortable.
- 2 to 3 weeks after the treatment any discomfort they feel is different than the pain they felt before the treatment. The “pain of an injured joint” is replaced with what is described as “the discomfort of a healing joint”.
- As the stem cells (biological allograft) do their work, “the discomfort of a healing joint”, slowly but surely goes away as the joint heals.
- For up to six months, the progression of the healing will continue.
Q. Should I preserve my daughter’s umbilical cord for use in my stem cell treatment?
A. There are numerous companies that will store embryonic tissues for delivering mothers. The hospital where the delivery will take place probably has a list of those approved by them. Does it make sense to do it?… things to consider.
- The longer the cells are frozen, the less likely they are to be viable.
- At the time you need them, there will be logistical and financial costs to harvesting them.
- As freshly harvested human umbilical cord stem cells (biological allograft) are highly viable, and completely safe to use, it stands to reason that storing one’s own embryonic cells may not be all that advantageous. However, the science of stem cell medicine is still in its infancy. If cost is not an issue, I personally would store them, just in case they have a unique – though currently unforeseeable – role to preserve the health of my family in the future.
Q. Have any neurological diseases been cured with stem cells?
A. Yes! Not only have mesenchymal stems cells (biological allograft) been used to arrest the progression of various neurological diseases, they have also been used to reverse and heal the disease. They do this by by stimulating the generation of new and healthy tissue.
Spinal cord breaks have also been successfully healed with these same cells.
There is ongoing research investigating the therapeutic effects of stem cells (biological allograft) on other neurological diseases. These include Alzheimer’s, ALS and Parkinson’s.
Other debilitating diseases, that are not neurological, are also being researched such as Muscular Dystrophy.
Q. How much does Stem Cell Therapy cost?
A. The cells (biological allograft) are expensive. However, for many conditions, they are far less expensive than conventional therapies. They also provide a far superior clinical outcome!
For example, a total knee replacement costs upwards of $70,000. Add on to that the 6 months of physical therapy rehabilitation and all the time away from work. Let’s not forget about all the possible complications and risks that major surgery and anesthesia comes with.
On the other hand, a stem cell injection in a knee may cost as little as $5,000. The treatment naturally heals the damage and regenerates the knee, completely avoiding surgery, etc, etc. The injection only takes a few minutes to perform, there is no downtime and virtually no negative side effects or risks!
Treatments for autoimmune conditions such as MS or RA typically require a series of stem cell infusions. Each of these infusions may contain many more CC’s than an injection and therefore more expensive. Each infusion typically costs $15,000 to $20,000. These infusions can be life-saving, restoring health and functionally and adding years to a patients life.
Q. What is the future for stem cell research?
A. In western medicine, the prevailing belief is that many illnesses and conditions can not be healed, let along cured. Once contracted, they become life-long afflictions, that at best, can be slowed down, but never quite stopped or reversed. Autoimmune diseases such as Diabetes, MS, Lupus, Celiac, Rheumatoid Arthritis, Crohn’s, Alzheimer’s and so many many others all fit into this category of diseases that will be with us until we die. The best we can hope for is to “manage” those diseases, to slow their progression, mask their symptoms and try to keep them from destroying our quality of life while they kill us prematurely.
Furthermore, as we age and our glands lose their vitality, our hormones fade, become imbalanced, and wreak havoc on our ability to function, feel good, and thrive. This too is considered “normal aging”, and therefore, from the conventional point of view, our best hope is to manage our decline and “age gracefully”… or more honestly stated, degenerate slowly.
The new science of Regenerative Medicine with stem cell therapies at its core, stands in stark contradistinction to this rather bleak and depressing conventional scenario. Central to its philosophy of clinical medicine, as well as to its scientific insight into human physiology is the notion that the regenerative capacity of every tissue and organ is a wellspring of potential that can be tapped, stimulated, harnessed and directed to revitalize organs and return them to youthful and healthy functionality. This vital regenerative life force is found in its purest and most potent form in stem cells (biological allograft), especially those harvested from embryonic tissues such as umbilical cords. (Note: Fetuses are NOT harmed in any way by the harvest of embryonic tissues)
Combined with other therapies that augment the regenerative forces within each cell, such as ozone therapies that greatly magnify mitochondrial function, degenerating joints, organs, glands, nerves and even brain, can be brought back into a state of health and vitality.
A rapidly growing number of major universities are now pursuing research in these areas, as are many major healthcare related corporations.
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- Anzalone R, Opatrilova R, Kruzliak P, Gerbino A and La Rocca G. Mesenchymal Stromal Cells From Wharton’s Jelly (WJ-MSCs): Coupling Their Hidden Differentiative Program to Their Frank Immunomodulatory Phenotype. 2018;20:271-279.
- Vangsness CT Jr, Sternberg H, Harris L. Umbilical Cord Tissue Offers the Greatest Number of Harvestable Mesenchymal Stem Cells for Research and Clinical Application: A Literature Review of Different Harvest Sites. 2015 Sep;31(9):1836-43.
- Watson N, Divers R, Kedar R, Mehindru A, Mehindru A, Borlongan M, Borlongan C. Discarded Wharton’s Jelly of the Human Umbilical Cord: A Viable Source for Mesenchymal Stem Cells. 2015 Jan;17(1):18–24.
- Kalaszczynska I, Ferdyn K. Wharton’s Jelly Derived Mesenchymal Stem Cells: Future of Regenerative Medicine? Recent Findings and Clinical Significance. 2015, Article ID 430847, 11 pages.
- Davies J, Walker J, Keating A. Concise Review: Wharton’s Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells. 2017 Jul;6(7):1620–1630.
- Weiss M, Troyer D. Stem Cells in the Umbilical Cord. 2006;2(2):155–162.
- Erices A, Conget P, Minguell J. Mesenchymal Progenitor Cells in Human Umbilical Cord Blood. 2000 Apr;109(1):235-42.
- Shawki S, Gaafar T, Erfan H, El Khateeb E, El Sheikhah A, El Hawary R. Immunomodulatory Effects of Umbilical Cord‐Derived Mesenchymal Stem Cells. 2015 Jun;59(6):348-56.
- Arutyunyan I, Elchaninov A, Makarov A, Fatkhudinov T. Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy. 2016;2016:6901286.
- SubramanianA, Fong C, Biswas A, Bongso A. Comparative Characterization of Cells from the Various Compartments of the Human Umbilical Cord Shows that the Wharton’s Jelly Compartment Provides the Best Source of Clinically Utilizable Mesenchymal Stem Cells. 2015 Jun;10(6):e0127992
- Ilic D, Polak JM. Stem Cells in Regenerative Medicine: Introduction. 2011;98:117-26.
- Sanchez-Ramos J. Stem Cells from Umbilical Cord Blood. 2006 Nov;24(5):358-69.
- Low CB, Liou YC, Tang BL. Neural Differentiation and Potential use of Stem Cells from the Human Umbilical Cord for Central Nervous System Transplantation Therapy. 2008 Jun;86(8):1670-9.
- Herranz AS, Gonzalo-Gobernado R, Reimers D, Asensio MJ, Rodríguez-Serrano M, Bazán E. Applications of Human Umbilical Cord Blood Cells in Central Nervous System Regeneration. 2010 Mar;5(1):17-22.
- Zarrabi M, Mousavi SH, Abroun S, Sadeghi B. Potential uses for Cord Blood Mesenchymal Stem Cells. 2014 Winter;15(4):274-81.
- Kabataş S, Civelek E, İnci Ç, Yalçınkaya EY, Günel G, Kır G, Albayrak E, Öztürk E, Adaş G, Karaöz E. Wharton’s Jelly-Derived Mesenchymal Stem Cell Transplantation in a Patient with Hypoxic-Ischemic Encephalopathy: A Pilot Study. 2018 Oct;27(10):1425-1433.
- Sadlik B, Jaroslawski G, Puszkarz M, Blasiak A, Oldak T, Gladysz D, Whyte G. Cartilage Repair in the Knee Using Umbilical Cord Wharton’s Jelly–Derived Mesenchymal Stem Cells Embedded Onto Collagen Scaffolding and Implanted Under Dry Arthroscopy. 2018 Jan;7(1):e57–e63.
- Kim DW, Staples M, Shinozuka K, Pantcheva P, Kang SD, Borlongan CV. Wharton’s Jelly-Derived Mesenchymal Stem Cells: Phenotypic Characterization and Optimizing Their Therapeutic Potential for Clinical Applications. 2013 May 31;14(6):11692-712.
- Nagamura-Inoue T, He H. Umbilical Cord-Derived Mesenchymal Stem Cells: Their Advantages and Potential Clinical Utility. 2014 Apr 26;6(2):195–202.