EBOO /F (Apheresis) Blood Cleansing

Extracorporeal Blood Oxygenation, Ozonation and Filtration.

Watch the video : How I Finally Healed from Lyme Disease – I Tried Everything!

EBOO /F is the most advanced minimally invasive intravenous therapies available to detox your blood. While there are a number of devices that can ozonate your blood in a precise and safe way, this is the only device that can actually filter your blood while it is being ozonated… and that is its greatest benefit.

Disclaimer: though everything represented on our website regarding the science of medical ozone comes directly from reputable publications, books and scientific journals; and though thousands of these articles are available on official NIH government websites (https://www.ncbi.nlm.nih.gov/pubmed/), and even though ozone therapy has been certified and authorized for treating viruses by other countries, they have not been evaluated by the Food and Drug Administration, and the FDA has not certified, endorsed or approved any of the scientific findings as methods of treating or diagnosing any diseases or illnesses.

What is EBOO /F (Apheresis)?

EBOO /F, also know as Recirculatory Hemoperfusion, Apheresis and Ozone Dialysis, is somewhat similar to dialysis, which filters out of your blood waste chemicals that healthy kidneys normally accomplish for you.

The EBOO/F is engineered to cleanse your blood of physical debris that your body is not capable of.

The EBOO /F is engineered to cleanse your blood of physical debris that your body is not capable of.

The EBOO /F is different in that it is engineered to cleanse your blood of physical debris that neither the kidneys nor liver are designed to do.

Why is the EBOO /F Filtration Important?

In cases of chronic infections, such as for example:

Even after the original pathogen has been killed, many patients still suffer debilitating symptoms that destroy their lives. Many Integrative physicians believe that this is due to residual “debris” left over from the infection. Endotoxins, cellular debris from dead pathogens, biofilm, micro clots and even debris from our own tissues damaged by the infection and the medications used to kill it. Our kidneys and liver are not designed to clear this debris, so it persists in our body as toxins that wreak havoc on us.

Debris being removed from the patient's blood. This debris will be captured by the EBOO/F filter. The purified, debris-free blood is then re-infused back into the patient.

Debris being removed from the patient’s blood. This debris will be captured by the EBOO /F filter. The purified, debris-free blood is then re-infused back into the patient.

The EBOO /F filtration is designed to clear this debris. We can actually see the “gunk” being sucked out of these patients, and captured by the filter, allowing purified blood to be re-infused back into them.

The toxic blood comes out of one arm, goes through the EBOO device, is filtered and ozonated, then the cleansed and ozonated blood goes into the other arm.

The toxic blood comes out of one arm, goes through the EBOO device, is filtered and ozonated, then the cleansed and ozonated blood goes into the other arm.

Many report immediate relief from their symptoms… literally during their first treatment with EBOO /F.

Explore the photos below to get an in-depth view of the debris the EBOO /F (apheresis) removes from the blood.

What Conditions can Benefit from EBOO /F?

EBOO /F is used to aid a variety of chronic diseases including:

  • Auto-immune Diseases
  • Diabetes
  • Long-Haul Covid
  • Lyme Disease
  • Herpes
  • Hepatitis
  • Brain fog
  • Chronic fatigue states
  • Chronic bladder conditions
  • Colitis
  • Crohn’s disease
  • Stroke
  • Hypertension
  • Eczema and Psoriasis
  • Lipid disorders
  • Cardiovascular disease
  • Peripheral Arterial Disease (PAD)
  • Coronary Disease
  • Severe Dyslipidemia
  • Madelung Disease
  • Necrotizing Fasciitis

Explore the photos below to get an in-depth view of the filter / dialyzer the EBOO /F uses to purify the blood.

Extracorporeal Blood Oxygenation, Ozonation and Filtration FAQs

A. There are numerous forms of Apheresis depending on what exactly is being filtered out of the blood.  Plasmapheresis is one of these forms.

The Apheresis device we are using is specifically designed to filter out of the blood, debris left over from chronic infections, such as endotoxins, particles of killed bacteria, cellular debris from damaged tissues, etc.

A. The procedure takes approximately an hour. In that time between 4 – 5 liters of blood are filtered.

The typical adult has on average 4.5-5.5 liters of blood.

A. Physical debris left over from chronic infections and systemic inflammation.

This includes:

  1. Endotoxins, which are fragments of pathogenic bacteria, fungus and mold infections that have been killed.
  2. Biofilm, which is a kind of sludge that many pathogenic microbes create to hide in… and where our immune cells can not penetrate.
  3. Debris from our own tissues that have been damaged from the infecting microbes and/or from powerful antimicrobial pharmaceutical drugs.
  4. Micro clots – microscopic blood clots that are resistant to the body’s own fibrinolytic processes.

Our kidneys and liver, which are extremely efficient in cleaning our blood from chemical toxins, are not good at cleaning the physical debris listed above.

A. As mentioned, the human body is not good at filtering the blood to get rid of toxic debris from chronic infections (see answer above). But to leave these toxic materials in the blood can make a person quite sick, and unable to function.

The body deals with this by storing these toxins in our tissues, and out of circulation. Tissues such as fat can store an enormous amount of toxic substances, including drugs and medications.

Additionally, all of our tissues are constructed within a system of Extracellular Matrix which holds our cells together. This ExtraCellular Matrix is designed to store an enormous amount of toxins away from the blood. 

Chelation therapy is designed to “shake loose” these toxins out of the tissues and back into the blood, where they can be successfully filtered and removed from your body.

A. Typically, IV chelation with a substance called EDTA is used. A great “side-benefit” derived from using chelation therapy is detoxification from Heavy Metals.

A. Depends on what condition your body is dealing with.

As a reference, our patients who are suffering from chronic Lyme symptoms even after a successful Lyme “kill”, generally need 4-6 sessions, once per week. Their results are best if they have a chelation IV early in the week and their EBOO /F treatment 2-3 days later.

A. In the USA, it is forbidden to say that a treatment is a “cure” for a condition if it has not been validated by the FDA. Thus we can not use the “cure” word no matter how effective the EBOO /F treatment is.

What we can say is: that the clinical results of using EBOO /F as a treatment for certain ailments is very effective compared to all other conventional treatments.

A. Yes. The blood comes out of one arm and the filtered blood is returned via the other arm.

A. Yes.

A. No. However, it would be helpful if you have had a blood test for the presence of the enzyme G6PD.

A. Most patients feel significantly better even during the treatment! Brain fog clears, energy comes back.

A. Yes.

A. If you have any kind of abnormal blood issues or bleeding issues, clotting, etc, we need to know about them.

A. Almost anybody. The main challenge is with people who have very poor veins, that are difficult to get good IV access.

Authored by Dr. Asher Milgrom | Reviewed by Dr. Alice Pien | Last updated:  


  1. N Di Paolo, E Gaggiotti, F Galli. Extracorporeal blood oxygenation and ozonation: clinical and biological implications of ozone therapy. 2005;10(3):121-30
  2. N Di Paolo, V Bocci, D P Salvo, G Palasciano, M Biagioli, S Meini, F Galli, I Ciari, F Maccari, F Cappelletti, M Di Paolo, E Gaggiotti. Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease. 2005 Oct;28(10):1039-50.
  3. Di Paolo N, Bocci V, Cappelletti F, Petrini G, Gaggiotti E. Necrotizing fasciitis successfully treated with extracorporeal blood oxygenation and ozonization (EBOO). 2002 Dec;25(12):1194-8.
  4. Wu J, Tan CS, Yu H, Wang Y, Tian Y, Shao W, Zhang Y, Zhang K, Shao H, Ni G, Shen J, Galoforo A, Wu Q, Ming D. Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy. 2020 Nov 4:100060.
  5. Rowen RJ. Ozone and oxidation therapies as a solution to the emerging crisis in infectious disease management: a review of current knowledge and experience. Med Gas Res. 2019 Oct-Dec;9(4):232-237.
  6. Belianin II, Shmelev EI. [Ozone therapy for protracted pneumonias]. Probl Tuberk Bolezn Legk. 2009;(3):28-33.
  7. Bocci VA, Zanardi I, Travagli V. Ozone acting on human blood yields a hormetic dose-response relationship. J Transl Med. 2011 May 17;9:66.
  8. Bocci V, Zanardi I, Travagli V, Di Paolo N. Oxygenation-ozonation of blood during extracorporeal circulation: in vitro efficiency of a new gas exchange device. Artif Organs. 2007 Sep;31(9):743-8.
  9. Di Paolo N, Bocci V, Garosi G, Borrelli E, Bravi A, Bruci A, Aldinucci C, Capotondo L. Extracorporeal blood oxygenation and ozonation (EBOO) in man. preliminary report. Int J Artif Organs. 2000 Feb;23(2):131-41.
  10. Moreno-Fernández A, Macías-García L, Valverde-Moreno R, Ortiz T, Fernández-Rodríguez A, Moliní-Estrada A, De-Miguel M. Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia. Acta Reumatol Port. 2019 Sep 29;44(3):244-249.